EssentialPIM Pro makes extensive use of shortcuts. Here is the list of them:

Global:

Ctrl+Alt+S Minimize to system tray

Shift+Ctrl+T New Appointment

Shift+Ctrl+O New To Do

Shift+Ctrl+N New Note

Shift+Ctrl+C New Contact

Shift+Ctrl+M New Message

Shift+Ctrl+P New Password Entry

Switching Between modules:

Ctrl+0 EPIM Today

Ctrl+1 Calendar

Ctrl+2 To Do

Ctrl+3 Notes

Ctrl+4 Contacts

Ctrl+5 Mail

Ctrl+6 Passwords

Ctrl+9 Trash

General:

Ctrl+L Hide/show private items

Ctrl+Q Focus on search box

Ctrl+Alt+F Advanced search

Shift+Ctrl+A Attachments manager

Database operations:

Ctrl+N New Database

Ctrl+O Open Database

Ctrl+S Save changes or New Database

Ctrl+P Print

In Calendar:

Ctrl+D Day View

Ctrl+W Week View

Ctrl+M Month View

Ctrl+R Year View

Ctrl+E Table View

Ctrl+T Today

Ctrl+G Go to

Ctrl+H Hide/Show completed

In To Do:

Ctrl+T Tree View

Ctrl+D Consolidated View

Ctrl+E Plain View

Ctrl+H Hide/show completed

Ctrl+K Show in Calendar

Ctrl+R Add to Root

Ctrl+Alt+Right  Move in

Ctrl+Alt+Left Move out

Ctrl+Alt+Up Move up

Ctrl+Alt+Down Move down

Ctrl+Alt+C Collapse All

Ctrl+Alt+X Expand All

In Notes:

Ctrl+R Add to root

Ins Add as Child

Ctrl+I Add as Sibling

Ctrl+Alt+Right  Move in

Ctrl+Alt+Left Move out

Ctrl+Alt+Up Move up

Ctrl+Alt+Down Move down

Ctrl+Alt+C Collapse All

Ctrl+Alt+X Expand All

while creating a new Note

Ctrl+D insert current Day

Ctrl+T insert current Time

In Contacts:

Ctrl+G Add Group

Ctrl+H Hide/show groups

In Mail:

Ctrl+R Reply to Sender

Ctrl+Shift+R Reply to All

Ctrl+W Forward

Ctrl+M Send

Ctrl+Alt+A Send and Receive All

Ctrl+Alt+R Receive All

Ctrl+Alt+X Send All

In Passwords:

Ctrl+G Add Group

Ctrl+H Hide/Show Groups

Ctrl+Alt+U Copy User Name

Ctrl+Alt+P Copy Password

Synchronization

Ctrl+Alt+G Google

Ctrl+Alt+Y Yahoo

Ctrl+Alt+F myFUNAMBOL

Ctrl+Alt+O AOLSync

Ctrl+Alt+N GooSync

Ctrl+Alt+T Toodledo

Ctrl+Alt+M Memotoo

Ctrl+Alt+E Stylite/Egroupwere

Ctrl+Alt+H HighRiseHQ

Ctrl+Alt+D CalDav

Ctrl+Alt+L SyncML

Ctrl+Alt+W Windows Mobile

Ctrl+Alt+U Outlook

In text editing standard shortcuts are enabled: Ctrl+X, Ctrl+C, Ctrl+V, Ctrl+Y, Ctrl+A.

All shortcuts could be edited under Tools -> Options -> Shortcuts dialog.